Ionic liquids as reaction media for oxidative folding and native chemical ligation of cysteine-containing peptides
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- 作者：Miriam Bö ; hm ; Alesia A. Tietze ; Pascal Heimer ; Ming Chen ; Diana Imhof ; dimhof@uni-bonn.de" class="auth_mail
- 关键词：[OAc]&minus ; acetate ; [C4mim]+ ; 1-butyl-3-methylimidazolium ; [N(CN)2]&minus ; dicyanamide ; [DEP]&minus ; diethylphosphate ; [DHP] ; dihydrogenphosphate ; EAF ; ethylammonium formate ; [C2mim]+ ; 1-ethyl-3-methylimidazolium ; HPLC ; high performance liquid chromatography ; IL ; ionic liquid ; MS ; mass spectrometry ; MALDI ; matrix-assisted laser desorption/ionization ; MAF ; methylammonium formate ; NCL ; native chemical ligation ; RTIL ; room temperature ionic liquid ; TFA ; trifluoroacetic acid ; TOF ; time of fligh
- 刊名：Journal of Molecular Liquids
- 出版年：April 2014
- 年：2014
- 卷：192
- 期：Complete
- 页码：67-70
- 全文大小：401 K
文摘
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Ionic liquids are useful solvents for peptide chemistry in solution phase.
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Imidazolium-based and alkylammonium-based protic ILs seem to be preferred.
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Oxidation of Cys-containing peptides occurs readily and selectively in ILs.
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Native chemical ligation of peptides in ILs is possible without additives.