Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR
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- 作者：Linara Gabitova1 ; 7 ; Diana Restifo1 ; Andrey Gorin1 ; 7 ; Kunal Manocha1 ; Elizabeth Handorf2 ; Dong-Hua Yang1 ; Kathy Q. Cai3 ; 4 ; Andres J. Klein-Szanto3 ; 4 ; David Cunningham5 ; Lisa E. Kratz6 ; Gail E. Herman5 ; Erica A. Golemis1 ; Igor Astsaturov1 ; 7 ; igor.astsaturov@fccc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 September 2015
- 年：2015
- 卷：12
- 期：11
- 页码：1927-1938
- 全文大小：3064 K
文摘
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NSDHL/SC4MOL loss induces the expression of LXR伪 transcriptional targets
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Nsdhl inactivation antagonizes the growth of KRasG12D-induced mouse skin papillomas
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EGFR inhibitors and LXR agonists synergistically suppress cancer cell growth