Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status
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- 作者：Yuan Chia ; Xiling Zhanga ; Zhen zhanga ; Takahiko Mitsuib ; Manabu Kamiyamab ; Masayuki Takedab ; Jian Yaoa ; yao@yamanashi.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cx ; connexin ; Cx43 ; connexin43 ; TJs ; tight junctions ; AJs ; adherens junctions ; GJs ; gap junctions ; siRNA ; small interfering RNA ; Cx43+/+ ; Cx43 wide-type mouse ; Cx43+/- ; Cx43 heterozygous mouse ; Cx43-/- ; Cx43 knockout mouse ; JNK ; c-Jun N-terminal kinase ; GSH ; glutathione ; FBS ; fetal bovine serum ; LY ; lucifer yellow ; SB203580 ; 4-(4-fluorophenyl)&minus ; 2-(4-methylsulfinylphenyl)&minus ; 5-(4-pyridyl)1H-imidazole ; SP600125 ; 2H-Dibenzo[cd ; g]indazol-6-one ; NAC ; N-acetyl-cysteine ; NRK ; Normal rat kidney
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：198-209
- 全文大小：3502 K
文摘
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The mechanisms about the coordinated regulation of cell junctions are obscure.
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Ca2+ depletion activates hemichannels and disrupts cell junctions.
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Hemichannel opening exaggerates oxidative stress via efflux of GSH.
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Blocking hemichannels attenuates oxidative stress and cell junction disassembly.
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Hemichannels regulate cell junctions via modulation of intracellular redox status.