Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis

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• 作者：Kasper ; Christoph ; Lü ; bking ; Anna ; Beelen ; Dietrich W. ; Dü ; hrsen ; Ullrich
• 关键词：Microenvironment ; Interferon-alpha ; Chronic myeloid leukaemia ; Monocytes&ndash ; macrophages ; Haematopoesis
• 刊名：Leukemia Research
• 出版年：2004
• 出版时间：November, 2004
• 年：2004
• 卷：28
• 期：11
• 页码：1217-1220
• 全文大小：61.0 K

文摘

Prolonged pre-transplant IFN administration in patients with chronic myeloid leukaemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation. Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on haematopoesis. This correlated with a decline in the number of monocytes–macrophages. While monocytes–macrophages itself produce cytokines, a vicious circle may lead to an ineffective function of the microenvironment resulting in ineffective haematopoieses and increased transplant-related complications.