In vitro monitoring of amyloid β-peptide oligomerization by Electrospray differential mobility analysis: An alternative tool to evaluate Alzheimer's disease drug candidates

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• 作者：Dimitri Brinet^a ; ^b ; Franç ; ois Gaie-Levrel^c ; Vincent Delatour^c ; Julia Kaffy^a ; Sandrine Ongeri^a ; Myriam Taverna^b ; ^{myriam.taverna@u-psud.fr}
• 关键词：Aβ ; Amyloid-beta peptide ; AD ; Alzheimer's disease ; CE ; Capillary Electrophoresis ; ThT ; Thioflavin-T ; TEM ; Transmission Electron Microscopy ; DC ; drug candidate ; SEC ; Size Exclusion Chromatography ; FCS ; fluorescence correlation spectroscopy ; FFF ; field flow fractionation ; ES-DMA ; Electrospray differential mobility analysis ; DMAS or SMPS ; Differential Mobility Analyzing System ; WCPC ; Water Condensation Particle Counter
• 刊名：Talanta
• 出版年：2017
• 出版时间：1 April 2017
• 年：2017
• 卷：165
• 期：Complete
• 页码：84-91
• 全文大小：876 K
• 卷排序：165

文摘

An Electrospray differential mobility analysis method for Aβ1-42 peptide oligomerization was developed. The size and proportion of the oligomers can be determined with good repeatability. We demonstrated the ability of ES-DMA to monitor oligomerization kinetics with or without drug candidates.