Novel genes in brain tissues of EAE-induced normal and obese mice: Upregulation of metal ion-binding protein genes in obese-EAE mice

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• 作者：Mahbub Hasan^a ; ^d ; Ji-Eun Seo^a ; ^d ; Khandoker Asiqur Rahaman^a ; ^d ; Hophil Min^b ; Ki Hun Kim^b ; Ju-Hyung Park^b ; Changmin Sung^b ; Junghyun Son^b ; Min-Jung Kang^c ; ^d ; Byung Hwa Jung^c ; ^d ; Won Sang Park^e ; Oh-Seung Kwon^a ; ^d ; ^{oskwon@kist.re.kr}
• 关键词：CNS ; central nervous system ; DEGs ; differentially expressed genes ; EAE ; experimental autoimmune encephalomyelitis ; GO ; gene ontology ; HFD ; high-fat diet ; MHC ; major histocompatibility complex ; MOG35-55 ; myelin oligodendrocyte glycoprotein 35&ndash ; 55 ; MS ; multiple sclerosis ; ND ; normal diet ; RT-PCR ; reverse-transcriptase polymerase chain reaction ; Th ; T-helper cells
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：322-336
• 全文大小：2587 K
• 卷排序：343

文摘

An aggravated EAE was observed in HFD-induced obese mice compared with ND-mice. Significantly upregulated genes in EAE were related to immune response, antigen presentation, complement activation, etc. C4b, Psmb8, Ly86, Ms4a6d, Cul9, and Mast2 are novel genes upregulated in both ND- and HFD-EAE mice. Cul9 and Mast2 genes of metal ion-binding proteins were upregulated in HFD-EAE mice than in ND-EAE mice.