Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma

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• 作者：Junfang Zheng^a ; ^b ; Lei Wang^c ; Zhiqiang Peng^a ; Ying Yang^d ; Duiping Feng^e ; Junqi He^a ; ^b ; ^{jq_he@ccmu.edu.cn}
• 关键词：ccRCC ; clear cell renal cell carcinoma ; PDZK1 ; PDZ domain containing 1 ; CAP70 ; cystic fibrosis transmembrane conductance regulator associated protein of 70  ; kDa ; DEPs ; differentially expressed proteins ; GO ; gene ontology ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; WB ; Western Blotting ; IHC ; immunohistochemistry ; iTRAQ ; isobaric tags for relative and absolute quantitaion ; FABP1 ; fatty acid binding protein 1 ; TCGA_KIRC ; The Cancer Genome Atlas kidney renal clear cell carcinoma ; NCCN ; natio
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：62-72
• 全文大小：1772 K
• 卷排序：15

文摘

PDZK1, which was involved in cell proliferation and lipid metabolism pathway, was significantly downregulated in ccRCC. PDZK1 was defined as an independent prognostic factor for OS and DFS in univariate and multivariate cox analyses. Low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.Clinical therapeutic effect varies greatly between individuals of clear cell renal cell carcinoma (ccRCC). Development of prognostic molecular biomarkers can help clinicians identify patients in need of early aggressive management. Differentially expressed proteins between tumor and adjacent normal tissues were analyzed by proteomics. Subsequently, bioinformatics assay was combined to screen for prognostic markers in ccRCC. PDZ domain containing 1 (PDZK1), involved in cell proliferation and lipid metabolism pathway, was significantly downregulated in ccRCC and defined as an independent prognostic factor for poor clinical outcome in ccRCC patients. Our findings will facilitate patient counseling and individualize management of patients with ccRCC.