Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
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- 作者：Xin Wang ; xinwang@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chunxu Hai ; cx-hai@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：6PGD ; 6-phosphogluconate dehydrogenase ; 20-HETE ; 20-hydroxyeicosatetraenoic acid ; AA ; arachidonic acid ; ADP ; adenosine diphosphate ; ADSCs ; adipose-derived stem cells ; aP2 ; fatty-acid binding protein ; AREs ; antioxidant response elements ; ATP ; adenosine triphosphate ; BAT ; brown adipose tissue ; β-catenin ; β-cadherin-associated protein ; BMDSCs ; Bone marrow-derived stems ; cAMP ; cyclic adenylyl monophosphate ; CAT ; catalase ; CD36 ; receptor for lipoproteins ; C/EBPs ; CCAAT/enhancer-binding proteins ; CHOP
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：99-125
- 全文大小：3298 K
文摘
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Imbalance of redox system is associated with obesity and obesity-related disorders.
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Redox system exerts “tridimensional” mechanism in the regulation of adipocyte differentiation.
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We propose that there is a complex and interactive “Redox Chain”.
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Redoxomics should be applied extensively to understand the mechanism of redox regulation.
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A “redox index” is needed to evaluate the general redox status.