Assessment of cochlear nerve deficiency and its effect on normal maturation of auditory tract by diffusion kurtosis imaging and diffusion tensor imaging: A correlational approach

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• 作者：Vijayakumar Chinnadurai^a ; ^{vijayakumar@inmas.drdo.in" class="auth_mail" title="E-mail the corresponding author} ; ^{vijayininmas@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; C.M. Sreedhar^b ; Subash Khushu^a
• 关键词：Diffusion kurtosis imaging ; Cochlear nerve deficiency ; Diffusion tensor imaging ; Diffusion weighted imaging
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：34
• 期：9
• 页码：1305-1313
• 全文大小：1247 K

文摘

The use of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) was evaluated in assessing cochlear nerve deficiency (CND) and its effect on normal maturation of auditory tract.

Methods

25 CND patients and 25 controls (age matched: 2 months to 17 years, gender matched) were evaluated by mean kurtosis (MK), axial kurtosis, and radial kurtosis and compared against fractional anisotropy (FA), axial and radial diffusivities in internal auditory canal (IAC), lateral lemniscus (LL) and inferior colliculus (IC). The age related changes of auditory tract were studied through Pearson correlation between estimated indices and age of both CND and control populations.

Results

Significant loss of MK (IAC: 10.71%, IC: 10.87%, LL: 15.63%) was observed in CND cases as against moderate reduction in FA (IAC: 8.57%, IC: 10%, LL: 7.69%) in all three anatomical locations. Similarly, substantial decline is observed in radial kurtosis (IAC: 27.03%, IC: 33.33%, LL: 31.43%) in comparison to moderate increase in radial diffusivity (IAC: 13.46%, IC: 24.39%, LL: 24%) in CND cases. No statistically significant change was seen in both axial kurtosis and diffusivities. In control populations, MK (r = 0.473, p = 0.011) and radial kurtosis (r = 0.418, p = 0.016) correlate positively with age and had no correlation in case of CND cases. FA (r = 0.356, p = 0.019) minimally correlated with age in control population but showed no statistically significant correlation in CND cases (r = 0.198, p = 0.036).

Conclusion

DKI metrics performed better than DTI in assessing microstructural changes of CND. In particular, MK and radial kurtosis are found to be more sensitive enough to differentiate the normal maturation of cochlear nerve from CND cases.