Synthesis and in vitro antitumor evaluation of dihydroartemisinin-cinnamic acid ester derivatives
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- 作者：Cang-Cang Xua ; Ting Denga ; Meng-Lin Fana ; Wen-Bo Lva ; Ji-Hua Liua ; liujihua@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; jihualiu88@163.com" class="auth_mail" title="E-mail the corresponding author ; Bo-Yang Yua ; b ; boyangyu59@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antitumor ; Dihydroartemisinin-cinnamic acid ester derivatives ; Apoptosis ; ROS ; Ferrous ion ; Oxidative stress
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：192-203
- 全文大小：1622 K
文摘
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Synthesis of a series of dihydroartemisinin-cinnamic acid hybrids.
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The antitumor activities of these compounds were evaluated.
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Compound 17 was the most potent anti-lung cancer agent.
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ROS and ferrous ion contributed to cell apoptosis induced by compound 17.
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A549 cells displayed higher ferrous ion and oxidation stress than normal hepatic L-02 cells.