Altered neuronal and endothelial nitric oxide synthase expression in the bladder and urethra of cyclophosphamide-treated rats
详细信息 查看全文
- 作者：Maria Sanchoa ; c ; Jose J. Ferreroa ; c ; Domingo Trigueroa ; c ; Magdalena Torresb ; c ; Angeles Garcia-Pascuala ; c ; angarcia@vet.ucm.es" class="auth_mail
- 关键词：ACh ; acetylcholine chloride ; AVP ; arginine vasopressin ; CYP ; cyclophosphamide ; DAPI ; 4&prime ; 6-diamino-2-phenylindole dihydrochloride ; EFS ; electrical field stimulation ; H&E ; haematoxylin and eosin ; ir ; immunoreactivity or immunoreaction ; NA ; noradrenaline ; l-NOARG ; NG-nitro-l-arginine ; LPS ; lipopolysaccharides from E. coli 026 ; B6 ; NO ; nitric oxide ; iNOS ; inducible nitric oxide synthase ; eNOS ; endothelial nitric oxide synthase ; nNOS ; neuronal nitric oxide synthase ; PB ; phosphate buffer ; p-eNOS
- 刊名：Nitric Oxide
- 出版年：30 May 2014
- 年：2014
- 卷：39
- 期：Complete
- 页码：8-19
- 全文大小：2696 K
文摘
- •
No iNOS was expressed in the bladder or urethra following CYP administration.
- •
CYP induces a transient downregulation of nNOS coincident with progressive eNOS upregulation.
- •
Changes in contractility were not associated with NO synthesis.
- •
Altered NO or free radical production mediated by constitutive NOS isoforms may contribute to CYP pathogenicity.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |