Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats

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• 作者：Rahul Deshmukh ; ^{login2rd@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Madhu Kaundal ; Vikas Bansal ; Samardeep
• 关键词：6-OHDA ; 6-hydroxydopamine ; ACh ; acetylcholine ; AChE ; acetylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; ANOVA ; analysis of Variance ; Aβ ; amyloid-beta ; BSA ; bovine serum albumin ; Caffeic acid ; 3 ; 4-dihydroxycinnamic acid ; DMSO ; dimethylsulfoxide ; DNPH ; 2 ; 4-dinitrophenylhydrazine ; DTNB ; 5 ; 5&prime ; -dithiobis-(2-nitrobenzoic acid) ; GSH ; reduced glutathione ; IAEC ; Institutional Animal Ethics Committee ; ICV ; intracerebroventrically ; INSA ; Indian National Science Academy ; MDA ; malondialdehyde ; MPTP ; 1
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：81
• 期：Complete
• 页码：56-62
• 全文大小：828 K

文摘

Oxidative stress has been implicated in cognitive decline as seen during normal aging and in sporadic Alzheimer’s disease (AD). Caffeic acid, a polyphenolic compound, has been reported to possess potent antioxidant and neuroprotective properties. The role of caffeic acid in experimental dementia is not fully understood. Thus the present study was designed to investigate the therapeutic potential of caffeic acid in streptozotocin (STZ)-induced experimental dementia of Alzheimer’s type in rats. Streptozotocin (STZ) was administered intracerebroventrically (ICV) on day 1 and 3 (3 mg/kg, ICV bilaterally) in Wistar rats. Caffeic acid was administered (10, 20 and 40 mg/kg/day p.o.) 1 h following STZ infusion upto 21st day. Morris water maze and object recognition task were used to assess learning and memory in rats. Terminally, acetylcholinesterase (AChE) activity and the levels of oxido-nitrosative stress markers were determined in cortical and hippocampal brain regions of rats. STZ produced significant (p < 0.001) learning and memory impairment, oxido-nitrosative stress and cholinergic deficit in rats. Whereas, caffeic acid treatment significantly (p < 0.001) and dose dependently attenuated STZ induced behavioral and biochemical abnormalities in rats. The observed cognitive improvement following caffeic acid in STZ treated rats may be due to its antioxidant activity and restoration of cholinergic functions. Our results suggest the therapeutic potential of caffeic acid in cognitive disorders such as AD.