Regulation and mechanism of leptin on lipid metabolism in ovarian follicle cells from yellow catfish Pelteobagrus fulvidraco
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- 作者：Li-Han Zhang ; Xiao-Ying Tan ; txy7933@163.com" class="auth_mail" title="E-mail the corresponding author ; txy7933@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Kun Wu ; Mei-Qin Zhuo ; Yu-Feng Song ; Qing-Ling Chen
- 关键词：ACC ; acetyl-CoA carboxylase ; CPT I ; carnitine palmitoyl transferase-I ; DMSO ; dimethyl sulphoxide ; FAS ; Fatty acid synthase ; G6PD ; glucose-6-phosphate dehydrogenase ; IRS&ndash ; PI3K ; insulin receptor substrate (IRS)&ndash ; phosphatidylinositol-3-OH-kinase ; JAK&ndash ; STAT ; Janus kinase/signal transducer and activator of transcription ; LepR ; leptin receptor ; PBS ; phosphate buffered saline ; PPAR ; peroxisome proliferators-activated receptor ; 6PGD ; 6-phosphogluconate dehydrogenase ; rt-hLEP ; recombinant
- 刊名：General and Comparative Endocrinology
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：222
- 期：Complete
- 页码：116-123
- 全文大小：1408 K
文摘
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Leptin incubation reduced intracellular TG content in ovarian follicles.
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Leptin reduced lipid deposition by activating lipolysis and suppressing lipogenesis.
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JAK–STAT and IRS–PI3K pathways were involved in the process of leptin action.