Injectable scaffolds: Preparation and application in dental and craniofacial regeneration

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• 作者：Bei Chang ; Neelam Ahuja ; Chi Ma ; Xiaohua Liu ; ^{xliu@tamhsc.edu}
• 关键词：BCP ; biphasic calcium phosphate ; BMMSC ; bone marrow-derived mesenchymal cells ; CPC ; calcium phaosphate cements ; DPSC ; dental pulp stem cell ; ECM ; extracellular matrix ; EDC ; 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride ; GAG ; glycosaminoglycan ; GelMA ; methacrylamide-functionalized gelatin ; H2O2 ; hydrogen peroxide ; HA ; hydroxyapatite ; HTCC ; N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride ; iPSMSC ; induced pluripotent stem cell-derived mesenchymal stem cell ; LCST ; lower cri
• 刊名：Materials Science and Engineering: R: Reports
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：111
• 期：Complete
• 页码：1-26
• 全文大小：8570 K
• 卷排序：111

文摘

Injectable scaffolds are appealing for tissue regeneration because they offer many advantages over pre-formed scaffolds. This article provides a comprehensive review of the injectable scaffolds currently being investigated for dental and craniofacial tissue regeneration. First, we provide an overview of injectable scaffolding materials, including natural, synthetic, and composite biomaterials. Next, we discuss a variety of characteristic parameters and gelation mechanisms of the injectable scaffolds. The advanced injectable scaffolding systems developed in recent years are then illustrated. Furthermore, we summarize the applications of the injectable scaffolds for the regeneration of dental and craniofacial tissues that include pulp, dentin, periodontal ligament, temporomandibular joint, and alveolar bone. Finally, our perspectives on the injectable scaffolds for dental and craniofacial tissue regeneration are offered as signposts for the future advancement of this field.