Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus

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• 作者：Simone Romano^a ; Nico Mitro^a ; Silvia Diviccaro^a ; Roberto Spezzano^a ; Matteo Audano^a ; Luis Miguel Garcia-Segura^b ; Donatella Caruso^a ; ^{donatella.caruso@unimi.it} ; Roberto Cosimo Melcangi^a ; ^{roberto.melcangi@unimi.it}
• 关键词：HMG-CoA R ; 3-hydroxy-3-methylglutaryl coenzyme A reductase ; 3α-diol ; 5alpha-androstane-3alpha ; 17beta-diol ; 3β-diol ; 5alpha-androstane-3beta ; 17beta-diol ; 5α-R ; 5alpha-reductase ; 7α-OH ; 7α-hydroxycholesterol ; 7β-OH ; 7β-hydroxycholesterol ; 7-keto ; 7-ketocholesterol ; DHCR24 ; 24-dehydrocholesterol reductase ; 24(S)-OH ; 24(S)-hydroxycholesterol ; 25-OH ; 25-hydroxycholesterol ; 27-OH ; 27-hydroxycholesterol ; P450scc ; cytochrome P450 side chain cleavage ; DHEA ; dehydroepiandrosterone ; (DHP) ; dihydroprogester
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：135-143
• 全文大小：581 K
• 卷排序：167

文摘

Short-term diabetes alters hippocampal steroidogenic machinery. Impaired cholesterol homeostasis contributes to altered hippocampal steroidogenesis. Mitochondrial dysfunction contributes to altered hippocampal steroidogenesis.