Is cleaved glucagon-like peptide 1 really inactive? Effects of GLP-1(9-36) on human adipose stem cells

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• 作者：Giulia Cantini^a ; Alessandra Di Franco^a ; Edoardo Mannucci^a ; ^b ; ^{edoardo.mannucci@unifi.it} ; Michaela Luconi^a ; ^{michaela.luconi@unifi.it}
• 关键词：Adipose stem cells ; Glucagon-like peptide-1 ; Alternative GLP-1R ; Dipeptidyl peptidase-4 inhibitors
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：10-15
• 全文大小：1127 K
• 卷排序：439

文摘

Glucagon-like peptide-1(9-36), the cleaved form of GLP-1, is active on human adipose stem cells (ASC) in vitro. GLP-1(9-36) inhibits ASC proliferation and adipogenesis, and induces cell apoptosis. These effects are not inhibited by exendin(9-39), suggesting a mechanism of action different from the classical GLP-1R.