Proteome analysis of acute kidney injury - Discovery of new predominantly renal candidates for biomarker of kidney disease

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• 作者：Pamella Araujo Malagrino^a ; ¹ ; ^{pamalagrino@gmail.com} ; ; Gabriela Venturini^a ; ¹ ; Patrí ; cia Schneider Yogi^a ; Rafael Dariolli^a ; Kallyandra Padilha^a ; Bianca Kiers^a ; Tamiris Carneiro Gois^a ; Karina Helena Morais Cardozo^b ; Valdemir Melechco Carvalho^b ; Jé ; ssica Silva Salgueiro^b ; Adriana Castello Costa Girardi^a ; Silvia Maria de Oliveira Titan^c ; José ; Eduardo Krieger^a ; Alexandre Costa Pereira^a ; ^{alexander.pereira@incor.usp.br} ;
• 关键词：Acute kidney injury ; Kidney disease ; Renal ischemia ; Proteome ; Biomarkers ; DPPIV
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：66-73
• 全文大小：1276 K
• 卷排序：151

文摘

Acute kidney disease is a leading cause of increased morbidity and mortality among patients with chronic diseases. Biomarkers for kidney disease are inaccurate and non-specific, increasing the time for a first diagnosis of acute conditions In addition, biomarkers for kidney disease not significantly adding to predictive algorithms By proteome analysis (tissue, serum, urine), we identify predominantly renal biomarkers with potential clinical applications; We were able to validate one of the identified markers in human samples from patients with known kidney disease. The identified biomarker dipeptidyl peptidase IV presented a good correlation with other measures of kidney dysfunction.