Stress granules at the intersection of autophagy and ALS
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- 作者：Zachary Monahana ; Frank Shewmakera ; Udai Bhan Pandeyb ; c ; d ; udai@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyotrophic lateral sclerosis ; Autophagy ; Motor neuron diseases ; Neurodegeneration ; Neuromuscular diseases ; P-bodies ; Protein degradation pathways ; Rapamycin ; Stress granules
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1649
- 期：part_PB
- 页码：189-200
- 全文大小：980 K
文摘
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Pathogenic mutations in ALS-associated genes have been shown to perturb autophagy pathways.
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Many ALS-associated proteins accumulate in cytoplasmic stress granules.
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Mutant ALS-causing proteins such as FUS, TDP-43, and SOD1 have been shown to be cleared by autophagy in cellular and human stem-cell derived neurons.