Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study
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- 作者：Rodrigo B. Mansura ; b ; rodrigomansur71@uol.com.br" class="auth_mail" title="E-mail the corresponding author ; Juhie Ahmeda ; Danielle S. Chaa ; Hanna O. Woldeyohannesa ; Mehala Subramaniapillaia ; Julie Lovshinc ; Jung G. Leea ; d ; Jae-Hon Leea ; e ; Elisa Brietzkeb ; Eva Z. Reininghausf ; Kang Simg ; Maj Vinbergh ; Natalie Rasgoni ; Tomas Hajekj ; Roger S. McIntyrea
- 关键词：Major depressive disorder ; Bipolar disorder ; Cognition ; Glucagon-like peptide-1 ; Liraglutide ; Insulin resistance
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：114-120
- 全文大小：423 K
文摘
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Cognitive deficits in mood disorders are highly prevalent and impactful.
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Few interventions have evidence of pro-cognitive effects in mood disorders.
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In this pilot study we explored the cognitive effect of a GLP-1 R agonist.
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4-week treatment with liraglutide was associated with cognitive improvements.
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Liraglutide was also safe and well tolerated by individuals with mood disorders.