Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights
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- 作者：Eduardo H.G. da Cruza ; Molly A. Silversb ; Guilherme A.M. Jardima ; Jarbas M. Resendea ; Bruno C. Cavalcantic ; Igor S. Bomfimc ; Claudia Pessoac ; d ; Carlos A. de Simonee ; Giancarlo V. Bottesellef ; Antonio L. Bragaf ; Divya K. Nairg ; Irishi N.N. Namboothirig ; David A. Boothmanb ; Eufrâ ; nio N. da Silva Jú ; niora ; eufranio@ufmg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-Lapachone ; Quinone ; Click chemistry ; Chalcogens ; Selenium
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：1-16
- 全文大小：1828 K
文摘
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Selenium-containing quinones were obtained with potent antitumor activity.
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Click chemistry was used for the synthesis of selenium-containing quinones.
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Mechanistic insights involving NQO1-target were studied.