Larock heteroannulation of 2-bromoanilines with internal alkynes via ligand and salt free Pd/C catalysed reaction

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• 作者：Nelly Batail^a ; ^{vdufaud@ens-lyon.fr} ; Vé ; ronique Dufaud^b ; ; Laurent Djakovitch^a ; ^{laurent.djakovitch@ircelyon.univ-lyon1.fr}
• 关键词：Larock synthesis ; Indole ; Pd catalysts ; Heterogeneous catalysis ; 2-Bromoanilines
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：20 April 2011
• 年：2011
• 卷：52
• 期：16
• 页码：1916-1918
• 全文大小：1468 K

文摘

An alternative to the use of ligands and homogeneous catalysis to promote the synthesis of 2,3-disubstituted indoles starting from 2-bromoanilines is described for the first time. This reaction could be achieved through a Larock heteroannulation via a ligand free heterogeneous catalysis.