Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

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• 作者：Ami Oi^a ; Syouichi Katayama^a ; ^b ; Naoya Hatano^c ; Yasunori Sugiyama^a ; Isamu Kameshita^a ; ; Noriyuki Sueyoshi^a ; ^{sueyoshi@ag.kagawa-u.ac.jp}
• 关键词：CDKL5 ; DYRK1A ; Protein phosphorylation ; Rett syndrome ; Down syndrome
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：239-245
• 全文大小：1040 K
• 卷排序：482

文摘

We investigated the mechanism regulating subcellular localization of CDKL5. DYRK1A was identified as an enzyme that bound to and phosphorylated CDKL5. The phosphorylation site of CDKL5 was Ser-308, in the vicinity of the NLS. When DYRK1A was co-expressed, the cytosolic CDKL5 was significantly increased. In conclusion, DYRK1A regulates CDKL5 localization via phosphorylation on Ser-308.