Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain
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- 作者：Jing Gonga ; c ; 1 ; Fang Dub ; c ; 1 ; Zhong Ming Qiana ; c ; qianzhongming@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qian Qian Luoc ; Yuan Shengc ; Wing-ho Yungb ; Yan Xin Xua ; Ya Keb ; yake@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; Ad-Hepcidin ; the recombinated-hepcidin-adenovirus ; BBB ; brain&ndash ; blood barrier ; BMECs ; brain microvascular endothelial cells ; DMT1 ; divalent metal transporter 1 ; Fpn1 ; ferroportin 1 ; GFAAS ; graphite furnace atomic absorption spectrophotometer ; NTBI ; non-transferrin-bound iron ; PD ; Parkinson&rsquo ; s disease ; ROS ; reactive oxygen species ; Tf-Fe ; transferrin-bound iron ; TfR1 ; transferrin receptor-1
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：126-132
- 全文大小：3578 K
文摘
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Pre-treatment with ad-hepcidin could increase hepcidin expression in the brain.
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The increased brain iron in iron-overload rat could be prevented by ad-hepcidin.
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The increased ROS in brain of iron-overload rat could be prevented by ad-hepcidin.
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Hepcidin prevents oxidative stress in the brain of iron overloaded rats.