Mechanisms of divalent metal toxicity in affective disorders

详细信息    查看全文

• 作者：Archita Venugopal Menon ; JuOae Chang ; Jonghan Kim ; ^{j.kim@neu.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BBB ; blood-brain barrier ; Cd ; cadmium ; CNS ; central nervous system ; Cu ; copper ; DMT1 ; divalent metal transporter 1 ; Fe ; iron ; Mn ; manganese ; NBIA ; neurodegeneration with brain iron accumulation ; Pb ; lead ; Se ; selenium ; ROS ; reactive oxygen species ; SOD ; superoxide dismutase ; Zn ; zinc
• 刊名：Toxicology
• 出版年：2016
• 出版时间：2 January 2016
• 年：2016
• 卷：339
• 期：Complete
• 页码：58-72
• 全文大小：1168 K

文摘

Metals are required for proper brain development and play an important role in a number of neurobiological functions. The divalent metal transporter 1 (DMT1) is a major metal transporter involved in the absorption and metabolism of several essential metals like iron and manganese. However, non-essential divalent metals are also transported through this transporter. Therefore, altered expression of DMT1 can modify the absorption of toxic metals and metal-induced toxicity. An accumulating body of evidence has suggested that increased metal stores in the brain are associated with elevated oxidative stress promoted by the ability of metals to catalyze redox reactions, resulting in abnormal neurobehavioral function and the progression of neurodegenerative diseases. Metal overload has also been implicated in impaired emotional behavior, although the underlying mechanisms are not well understood with limited information. The current review focuses on psychiatric dysfunction associated with imbalanced metabolism of metals that are transported by DMT1. The investigations with respect to the toxic effects of metal overload on behavior and their underlying mechanisms of toxicity could provide several new therapeutic targets to treat metal-associated affective disorders.