Intraventricular Gliosarcomas: Literature Review and a Case Description

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• 作者：Ramesh S. Doddamani<sup>1sup><sup> ; sup><sup>drsdramesh@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Rajesh K. Meena<sup>2sup> ; Murli M. Selvam<sup>3sup> ; Neelam K. Venkataramanaa<sup>3sup> ; Madhvi Tophkhane<sup>4sup> ; Sharat K. Garg<sup>3sup>
• 关键词：Cystic gliosarcoma ; Mural nodule ; Intraventricular tumor
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：90
• 期：Complete
• 页码：707.e5-707.e12
• 全文大小：2089 K

文摘

Gliosarcomas are rare, extremely high-grade, bimorphous malignant tumors of the central nervous system. Intraventricular location is extremely rare, and only a few case reports exist in the literature. The aim of our study is to review clinical, radiologic, and pathologic features of this unique oncological entity and report this rare case of primary cystic intraventricular gliosarcoma (IVGS) with a mural nodule.

sSec_2">Methods

spara0015">A 23-year-old man had a 6-month history of headache and a single episode of generalized seizure. Examination revealed grade 1 papilledema. Brain magnetic resonance imaging revealed a cystic lesion with a mural nodule located within the occipital horn of the right lateral ventricle, which exhibited an intense enhancement of the nodule with patchy rim enhancement of the wall on gadolinium administration. The patient underwent right parietal craniotomy and gross total excision of the tumor.

sSec_3">Results

spara0020">Postoperative computed tomography of the brain showed evidence of complete tumor excision. The postoperative course of the patient was uneventful. Histopathologic analysis revealed malignant tumor comprising both glial and mesenchymal components suggestive of gliosarcoma.

sSec_4">Conclusion

spara0025">Primary IVGS is an extremely rare malignancy, with only 9 cases reported in the literature, and it should be considered in the differential diagnosis of lateral ventricular tumors.