Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS
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- 作者：Minami Hasegawaa ; b ; Chikako Hara-Miyauchia ; b ; Hiroki Ohtaa ; c ; Kenji Sakimurad ; Hideyuki Okanob ; hidokano@a2.keio.jp" class="auth_mail" title="E-mail the corresponding author ; Hirotaka James Okanoa ; b ; hjokano@jikei.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALS ; Biomarker ; TDP-43 ; RNA metabolism ; Peripheral blood cells
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：106
- 期：Complete
- 页码：12-22
- 全文大小：2163 K
文摘
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To identify the biomarker of ALS, two kinds of mutant TDP-43 KI mice were used.
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Metabolisms of TDP-43 were changed in astrocytes and WBCs of mutant TDP-43 KI mice.
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Combination of survival and apoptosis-related factors may become a biomarker of ALS.
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