- 作者：Nagila R.T. Damasceno ; Aleix Sala-Vila ; Montserrat Cof¨¢n ; Ana M. P¨¦rez-Heras ; Montserrat Fit¨® ; Valentina Ruiz-Guti¨¦rrez ; Miguel-¨¢ngel Mart¨ªnez-Gonz¨¢lez ; Dolores Corella ; Fern ; o Ar¨®s ; Ramon Estruch ; Emilio Ros
- 关键词：HDL size ; LDL size ; Nuts ; Olive oil ; PREDIMED ; Small-dense LDL ; Triglycerides ; VLDL size
- 刊名：Atherosclerosis
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：230
- 期：2
- 页码：347-353
- 全文大小：293 K
Objective
The PREDIMED trial showed that Mediterranean diets supplemented with either extra-virgin olive oil or nuts reduced incident cardiovascular events compared to a control diet. Consumption of both supplemental foods has been associated with reduced LDL-cholesterol, but it is unknown whether they can shift lipoprotein subfractions to a less atherogenic pattern. We investigated changes in adiposity and lipoprotein subfractions after consumption of the PREDIMED diets.Methods
In a PREDIMED sub-cohort (n?=?169), lipoprotein subclasses (particle concentrations and size) were determined by nuclear magnetic resonance spectroscopy at baseline and after intervention for 1 year.
Results
Participants allocated to the Mediterranean diet supplemented with nuts showed significant reductions from baseline of waist circumference (mean [95 % CI];??5?cm [?7;??3]) and concentrations of medium-small (?27?nmol/l [?46;??8]) and very small LDL (?111?nmol/l [?180;??42]); decreased LDL particle number (a nuclear magnetic resonance-specific measurement) (?98?nmol/l [?184;??11]); and an increase of large LDL concentrations (54?nmol/l [18; 90]), with a net increase (0.2?nmol/l [0.1; 0.4]) of LDL size. The Mediterranean diets with olive oil and nuts increased large HDL concentrations (0.6?¦ÌM [0.0; 1.1] and 1.0?¦ÌM [0.4; 1.5], respectively). Compared to the other two intervention groups, participants in the nut-enriched diet showed significantly reduced waist circumference (p?¡Ü?0.006, both) and increased LDL size (p?<?0.05, both).
Conclusion
Lipoprotein subfractions are shifted to a less atherogenic pattern by consumption of Mediterranean diets enriched with nuts. The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial.