A comparative study between limb-salvage and amputation for treating osteosarcoma

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• 作者：Xiaojuan Li^a ; ¹ ; Ya Zhang^a ; ¹ ; Shanshan Wan^b ; ¹ ; Huiling Li^a ; ¹ ; Dongqi Li^a ; Junfeng Xia^a ; Zhongqin Yuan^a ; Mingyan Ren^a ; Shunling Yu^a ; Su Li^a ; Yihao Yang^a ; Lei Han^b ; Zuozhang Yang^a ; ¹ ; ^{yangzuozhang@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：LSS ; limb salvage surgery
• 刊名：Journal of Bone Oncology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：5
• 期：1
• 页码：15-21
• 全文大小：456 K

文摘

Osteosarcoma is an aggressive malignant neoplasm, and conflicting findings have been reported on the survival and function recovery in osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared clinical outcomes regarding limb salvage surgery vs. amputation for osteosarcoma patients by a meta-analysis.

Method

Literature search was conducted in CNKI, Medline, Embase, the Cochrane Database, and Web of Sciences, and the quality of included studies was evaluated based on Newcastle-Ottawa scale quality assessment. Odds ratio and 95% confidence interval of the local recurrence, 5-year overall survival, and metastasis occurrence were calculated.

Results

17 articles were included according to selection criteria. There were 1343 patients in total derived from these studies. Our result showed that there was no significant difference between limb salvage surgery and amputation with respect to local recurrence, and patients with limb salvage surgery had a higher 5-year overall survival, and a lower metastasis occurrence.

Conclusions

The present study provided more comprehensive evidences to support limb salvage surgery as an optimal treatment of osteosarcoma patients.