Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2
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- 作者：Jihe Lia ; Dongxia Tongb ; Juan Liuc ; Fuyang Chend ; Yongbin Shene ; shenyongbin11@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oroxylin A ; Cigarette smoke ; Nrf2
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：524-529
- 全文大小：1272 K
文摘
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Oroxylin A attenuated CS-induced lung histopathologic changes, expression of cytokines TNF-α, IL-1β, and MCP-1.
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Oroxylin A inhibited the levels of oxidative biomarkers 3-nitrotyrosine and 8-isoprostane.
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Oroxylin A up-regulated GSH level and glutathione reductase (GR) activity in lung tissues.
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In vitro, oroxylin A significantly up-regulated Nrf2 expression and total cellular glutathione level in CSE-stimulated cells.
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In addition, oroxylin A promoted heme oxygenase-1, GPx, and GR expression in CSE-stimulated cells.