Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

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• 作者：Ning Zhang^a ; ^b ; Yan Hu^b ; Chunchun Ding^a ; Wenjing Zeng^a ; Wen Shan^a ; Hui Fan^b ; Yan Zhao^a ; Xue Shi^a ; Lili Gao^a ; Ting Xu^a ; Ruiwen Wang^a ; Dongyan Gao^a ; Jihong Yao^a ; ^{yaojihong65@hotmail.com}
• 关键词：Salvianolic acid B ; SIRT1 ; Alcoholic liver injury ; ChREBP ; CRP
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：1-10
• 全文大小：2378 K
• 卷排序：267

文摘

This is the first report demonstrating that SalB ameliorates ALD in rats. SalB alleviates ALD involved SIRT1-mediated inhibition of CRP and ChREBP. HNF-1α is involved in SIRT1-mediated inhibition of CRP expression.