Hypoxia induces TWIST-activated epithelial-mesenchymal transition and proliferation of pancreatic cancer cells in vitro and in nude mice
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- 作者：Shi Chena ; b ; c ; Jiang-zhi Chenb ; Jia-qiang Zhanga ; c ; Hui-xin Chenb ; Mao-lin Yana ; Long Huanga ; Yi-feng Tiana ; Yan-lin Chenb ; drchenyl@126.com" class="auth_mail" title="E-mail the corresponding author ; Yao-dong Wanga ; wangyaodongch@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic cancer ; Hypoxia ; EMT ; TWIST ; Prognosis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：73-84
- 全文大小：3759 K
文摘
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TWIST overexpression promoted tumor cell growth and EMT under a hypoxic condition.
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TWIST is a negative regulator of E-cadherin and P16 in PDAC.
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TWIST interacted with Ring1B and EZH2.
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TWIST recruited Ring1B and EZH2 to the E-cadherin and p16 promoter regions.