Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents
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- 作者：Maojiang Wu ; Qiming Sun ; Chunhao Yang ; Dongdong Chen ; Jian Ding ; Yi Chen ; Liping Lin ; Yuyuan Xie
- 关键词：Combretastatin A-4 analogue ; 1 ; 2 ; 3-Thiadiazoles ; Tubulin ; Antitumor
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：15 February 2007
- 年：2007
- 卷：17
- 期：4
- 页码：869-873
- 全文大小：498 K
文摘
A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity.