Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1
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- 作者：Qingzhan Zhang1 ; Kaichuang Shi1 ; 2 ; Dongwan Yoo ; dyoo@illinois.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CREB-binding protein ; Porcine epidemic diarrhea virus ; Coronavirus ; Interferon regulation ; CBP ; Nsp1 ; Innate immune signaling
- 刊名：Virology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：489
- 期：Complete
- 页码：252-268
- 全文大小：4369 K
文摘
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PEDV modulates the host innate immune system by suppressing the type I interferon production and ISGs expression.
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Ten viral proteins were identified as IFN antagonists, and nsp1 was the most potent viral IFN antagonist.
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PEDV nsp1 did not interfere the IRF3 phosphorylation and nuclear translocation but interrupted the enhanceosome assembly of IRF3 and CREB-binding protein (CBP).
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PEDV nsp1 caused the CBP degradation in the nucleus, which may be the key mechanism for PEDV-mediated IFN downregulation.