Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8⁺ T-cells favoring anti-tumor immunity

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• 作者：Claudio Figueroa^a ; ^b ; Felipe Gá ; lvez-Cancino^c ; ^d ; Cesar Oyarce^c ; Francisco Contreras^a ; Carolina Prado^a ; Catalina Valeria^a ; Sebastiá ; n Cruz^c ; Alvaro Lladser^c ; Rodrigo Pacheco^a ; ^d ; ^{rpacheco@cienciavida.org} ; ^{rodrigo.pacheco@unab.cl}
• 关键词：Dendritic cells ; Cytotoxic T lymphocytes ; Dopamine receptors ; Tumor immunology ; Antigen cross-presentation ; Knockout mice
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：99-107
• 全文大小：832 K
• 卷排序：303

文摘

Dopamine receptor D3 signaling reduces antigen cross-presentation in dendritic cells. Dopamine receptor D3 antagonism in dendritic cells increases CD8+ T-cells response. Dopamine receptor D3 deficiency in dendritic cells strengthens anti-tumor immunity.