DNA methylation markers for oral pre-cancer progression: A critical review
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- 作者：Krithiga Shridhara ; 1 ; g.krithiga@phfi.org" class="auth_mail" title="E-mail the corresponding author ; Gagandeep Kaur Waliaa ; 1 ; Aastha Aggarwala ; Smriti Gulatia ; A.V. Geethaa ; Dorairaj Prabhakarana ; b ; c ; Preet K. Dhillona ; Preetha Rajaramand
- 关键词：DNA methylation ; Oral pre-cancer ; Bio-marker ; Epigenetics ; Leukoplakia ; Oral sub-mucous fibrosis ; Promoter regions ; CpG sites ; Tumour suppressor genes ; Diagnostic marker
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：1-9
- 全文大小：764 K
文摘
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We critically reviewed DNA methylation patterns for oral pre-cancer progression.
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Suggestive signals included hyper-methylated loci in p16, p14, MGMT and DAPK.
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Large epigenome-wide explorations are needed to validate these markers and to identify new risk loci and biological pathways of disease progression.
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