The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation

详细信息    查看全文

• 作者：Gerald J. Berry ; Margaret M. Burke ; Claus Andersen ; Patrick Bruneval ; Marny Fedrigo ; Michael C. Fishbein ; Martin Goddard ; Elizabeth H. Hammond ; Ornella Leone ; Charles Marboe ; Dylan Miller ; Desley Neil ; Doris Rassl ; Monica P. Revelo ; Alex ; ra Rice ; E. Rene Rodriguez ; Susan Stewart ; Carmela D. Tan ; Gayle L. Winters ; Lori West ; et al.
• 关键词：heart ; antibody mediated rejection ; immunohistochemistry ; immunofluorescence ; intravascular ; activated mononuclear cells ; complement
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：December, 2013
• 年：2013
• 卷：32
• 期：12
• 页码：1147-1162
• 全文大小：9341 K

文摘

During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.