Inherent functional dependence among cochlear dose surrogates for stereotactic radiosurgery of vestibular schwannomas

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• 作者：Lijun Ma ; PhD^a ; ^{lijun.ma@ucsf.edu} ; Steve E. Braunstein ; MD ; PhD^a ; Philip V. Theodosopoulos ; MD^b ; Michael W. McDermott ; MD^b ; Penny K. Sneed ; MD^a
• 刊名：Practical Radiation Oncology
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：7
• 期：1
• 页码：e1-e7
• 全文大小：676 K
• 卷排序：7

文摘

Various cochlear dose surrogates have been reported as associated with hearing outcome in studies of stereotactic radiosurgery (SRS) for vestibular schwannomas. In this study, we investigated whether an inherent functional relationship exists among these reported surrogates.Methods and materialsA cohort of 85 serial patient cases treated with single-fraction stereotactic radiosurgery from 1997 through 2013 at our institution was analyzed. For all the cases, the mean prescription dose was 12.5 ± 0.3 Gy (range, 12-13 Gy) and mean target volume 1.32 ± 1.51 mL (range, 0.80-8.77 mL). The mean cochlea volume was 0.078 ± 0.016 mL (range, 0.048-0.131 mL; median, 0.076 mL). Correlation analysis among mean cochlear dose, point maximum dose and modiolus dose was performed and also parameterized with new variables such as the effective dose radius (EDR) as derived from a general dose fall-off model.ResultsWeak correlation via linear regression was found between the point maximum dose and the mean cochlear dose (R2 = 0.719) as well as the modiolus dose (R2 = 0.568). However, when parameterized with EDR, a near-perfect correlation (P < .0001) via linear regression was found between the EDR for the point maximum dose and the EDR for the mean cochlear dose (R2 = 0.996), and with the EDR for the modiolus dose (R2 = 0.993). Such a result led to a functional formula relating these dose surrogates, yielding dose equivalence results such as: 12-Gy point maximum dose is equivalent to mean cochlear dose of 5.6 ± 0.1 Gy (95% confidence level), or modiolus dose of 6.0 ± 0.2 Gy (95% confidence level).ConclusionsAn inherent functional relationship was found among point maximum, modiolus, and mean cochlear doses for SRS of vestibular schwannomas. As such, clinical hearing outcome can be interchangeably analyzed or reported via any of these dose surrogates.