New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases
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- 作者：Xin Liua ; 1 ; Yun-Feng Caob ; 1 ; Rui-Xue Ranc ; Pei-Pei Donge ; Frank J. Gonzalezh ; Xue Wuf ; g ; Ting Huangb ; Jian-Xin Chenb ; Zhi-Wei Fuf ; g ; Rong-Shan Lic ; Yong-Zhe Liud ; Hong-Zhi Suna ; ; Zhong-Ze Fangd ; fangzhongze@tmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phthalates ; UDP-glucuronosyltransferases (UGTs) ; Di-n-octyl ortho-phthalate (DNOP) ; Diphenyl phthalate (DPhP)
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：1966-1972
- 全文大小：1448 K
文摘
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Di-n-octyl ortho-phthalate (DNOP) and diphenyl phthalate (DPhP) exhibited strong inhibition towards UGT1A3.
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More hydrogen bonds contributed the stronger inhibition of DPhP towards UGT1A3 than DNOP.
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DPhP competitively inhibited UGT1A3 with the inhibition kinetic parameter (Ki) to be 0.65 µM.