Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo
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- 作者：Nadine Madeleine Rossiera ; b ; Geraldine Chewa ; Kun Zhanga ; Francesco Rivac ; Karl Fenta ; d ; karl.fent@fhnw.ch" class="auth_mail" title="E-mail the corresponding author ; karl.fent@bluewin.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：DRS ; drospirenone ; P4 ; progesterone ; MPA ; medroxyprogesterone acetate ; DDG ; dydrogesterone ; CA ; concentration addition ; AR ; androgen receptor ; ER ; estrogen receptor ; PR ; progesterone receptor ; MR ; mineralocorticoid receptor ; hpf ; hours post fertilization ; EC ; effect concentrations
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：174
- 期：Complete
- 页码：109-122
- 全文大小：3937 K
文摘
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Synthetic progestin drospirenone was assessed as single compound and in mixtures.
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Mixtures of drospirenone with P4 and estrogen were assessed in vitro and in vivo.
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Mixture activities in vitro were mostly additive.
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Mixture activities in zebrafish eleuthero-embryos were more complex.
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Equi-effective mixtures of DRS and EE2 showed antagonistic interactions in vivo.