Hypothermia-induced ischemic tolerance is associated with Drp1 inhibition in cerebral ischemia-reperfusion injury of mice
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- 作者：Yingying Tanga ; b ; Xiaojie Liuc ; Jie Zhaoa ; Xueying Tane ; Bing Liua ; Gaofeng Zhangd ; Lixin Sund ; Dengyang Hana ; Huailong Chend ; chenhuailongdr@163.com" class="auth_mail" title="E-mail the corresponding author ; Mingshan Wanga ; d ; wangmingshandr@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drp1 ; Dynamin related protein 1 ; Cyto C ; Cytochrome C ; TUNEL ; Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling ; HT ; hypothermia ; NT ; normothermia ; IR ; ischemia-reperfusion
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：73-83
- 全文大小：8729 K
文摘
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Ischemia-reperfusion (IR) injury increased Drp1 activation and Cytochrome C release.
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Hypothermia significantly attenuated brain IR injury by reduce cell apoptosis.
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Hypothermia inhibited IR-induced elevated Drp1 activation, and Cytochrome C release to cytosol.