Usefulness of CHADS₂ score for prognostic stratification of patients with coronary artery disease: A systematic review and meta-analysis of cohort studies

详细信息    查看全文

• 作者：Xiaobo Zhou^a ; ¹ ; ^{zhxiaobo@sohu.com} ; Kaiwu Cao^a ; ¹ ; ^{183580422@qq.com} ; Shuangqing Kou^a ; ^{2405893700@qq.com} ; Shencheng QU^a ; ^{287633353@qq.com} ; Hongling Li^b ; ^{lihonglinglhl@163.com} ; Ying Yu^a ; ^{276137869@qq.com} ; Cong Wang^a ; ^{wangcong19840119@126.com} ; Yu Liu^a ; ^{yuying0021@sina.com} ; Pengying Li^a ; ^{87044339@qq.com} ; Dan Li^a ; ^{Ld26615406@163.com}
• 关键词：Coronary artery disease ; Atrial fibrillation ; CHADS2 score ; Death ; Stroke ; Risk ratio
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：906-911
• 全文大小：671 K
• 卷排序：228

文摘

To evaluate the role of CHADS2 score on predicting ischaemic stroke or transient ischaemic attack (TIA) and death in patients with coronary artery disease (CAD), irrespective of the presence or absence of atrial fibrillation (AF).MethodsWe searched for cohort studies that reported risk estimates for incidence of ischaemic stroke/TIA or mortality by levels of CHADS2 score in Medline/PubMed and Embase. Random effects models were used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs).ResultsEight cohort studies (7 prospective and 1 retrospective) enrolling 31,509 patients with CAD were included. The pooled RR of mortality was 2.38 (95% CI 1.63–3.47) for CHADS2 score 0;≥ 0;2, and of stroke/TIA incidence was 2.19 (1.55–3.08). In patients without AF, CHADS2 score 0;≥ 0;2 was associated with increased mortality (pooled RR 3.14 95% CI 2.14–4.61) and stroke/TIA incidence (pooled 2.81, 2.08–3.78) In patients with AF, the pooled RR of mortality for CHADS2 score 0;≥ 0;2 was 1.57 (1.07–2.28), but no significant association was found between CHADS2 score and stroke/TIA incidence (pooled RR 1.21, 95% CI 0.84–1.73).ConclusionsCHADS2 score can predict mortality in patients with CAD. However, higher CHADS2 score is associated with increased incidence of stroke/TIA only in patients without AF.