Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice
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- 作者：Priyam H. Jani ; Monica P. Gibson ; Chao Liu ; Hua Zhang ; Xiaofang Wang ; Yongbo Lu ; Chunlin Qin ; cqin@bcd.tamhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone ; Dentin matrix protein 1 ; Dentin sialophosphoprotein ; Mineralization ; Transgenic mice
- 刊名：Matrix Biology
- 出版年：2016
- 出版时间：May-July 2016
- 年：2016
- 卷：52-54
- 期：Complete
- 页码：95-112
- 全文大小：3839 K
文摘
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Transgenic expression of Dspp lengthened the long bone of Dmp1-null mice.
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Dspp transgenic expression improved the cortical bone of Dmp1-null mice.
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Dspp overexpression improved the collagen network of Dmp1-deficient bone.
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Overexpressing Dspp improved the lacunocanalicular system of Dmp1-deficient bone.
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Transgenic Dspp corrected the altered levels of ECM molecules in Dmp1-deficient bone.
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