文摘
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Background
It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility.Objective
<p>To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma.Design
<p>Secondary analysis of the Polyp Prevention Trial (PPT) data.Setting
<p>United States.Patients
<p>Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy.Main Outcome Measurements
<p>Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees.Results
<p>Blacks had similar risk of recurrence of adenoma (39.2 % vs 39.4 % ; incidence risk ratio [RR] = .98; 95 % CI, .80-1.20) and advanced adenoma (8.5 % vs 6.4 % ; RR = 1.18; 95 % CI, .68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3 % vs 67.0 % ; RR = 1.01; 95 % CI, .84-1.21) and advanced adenoma (14.5 % vs 16.9 % ; RR = 1.03; 95 % CI, .60-1.79).Limitation
<p>There were few blacks in the long-term follow-up study.Conclusions
<p>Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.
