A new biorelevant dissolution method for orodispersible films
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- 作者：Raphael Krampe raphael.krampe@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Daniel Sieber daniel.sieber@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Miriam Pein-Hackelbusch miriam.pein@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Jö ; rg Breitkreutz ; joerg.breitkreutz@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Orodispersible films ; Dissolution testing ; Biorelevant method ; In-line measurement ; Ketoprofen
- 刊名：European Journal of Pharmaceutics and Biopharmaceutics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：20-25
- 全文大小：728 K
文摘
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Development of a new biorelevant dissolution method for orodispersible films.
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Comparison of conventional methods and the new biorelevant dissolution method.
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Feasibility and problems of different dissolution setups for orodispersible films.
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Conventional dissolution setups show faster concentration onset.
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Simulated saliva flow has a higher impact on the dissolution than mechanical force.