Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population

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• 作者：Tran Quang Binh^a ; ^{binhtq@nihe.org.vn} ; Pham Tran Phuong^a ; ^{pt_phuong24@yahoo.com} ; Bui Thi Nhung^b ; ^{nhungvnnin@yahoo.com} ; Dang Dinh Thoang^c ; ^{thoangyt@yahoo.com} ; Ha Thi Lien^a ; ^{halien421@gmail.com} ; Duong Van Thanh^a ; ^{dvthanh83@yahoo.com}
• 关键词：T2D ; type 2 diabetes ; FTO ; fat mass and obesity associated ; OR ; odd ratio ; CI ; confidence interval ; OGTT ; oral glucose tolerance test ; FPG ; fasting plasma glucose test ; HDL-C ; high-density lipoprotein-cholesterol ; LDL-C ; low-density lipoprotein-cholestero
• 刊名：Gene
• 出版年：2013
• 出版时间：15 January, 2013
• 年：2013
• 卷：513
• 期：1
• 页码：31-35
• 全文大小：276 K

文摘

Type 2 diabetes (T2D) is a complex disorder resulting from both genetic and environmental factors in its pathogenesis. A case ? control study was designed with subjects recruited from a general population to investigate whether the association between T2D and the common T > A polymorphism (rs9939609) in fat mass and obesity associated (FTO) gene is mediated by obesity-related measurements, considering the contribution of socio-economic status and lifestyle factors. The significant association between the FTO rs9939609 polymorphism and T2D was first observed in the model unadjusted (OR per A allele = 1.61, 95 % CI = 1.06-2.44, P = 0.024). It remained consistently replicated in the final model after adjustments for sex, age, systolic blood pressure, socio-economic status, lifestyle factors, and obesity-related measurements (body mass index, waist-hip ratio, body fat percentage, and body adiposity index), showing an increased T2D risk with an additive effect of the alleles (ORs per A allele = 1.80-1.92, 95 % CI = 1.09-3.19, P < 0.05). The FTO-rs9939609 polymorphism, systolic blood pressure, and waist-hip ratio were the most significant independent predictors for T2D, in which the power of the adjusted prediction model was 0.769. In conclusion, the study suggested that the FTO-rs9939609 polymorphism was significantly associated with the increased risk of T2D, independent of obesity-related measurements in a Vietnamese population.