Dupuytren’s disease susceptibility gene, EPDR1, is involved in myofibroblast contractility
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- 作者：Kim A. Staatsa ; Timothy Wua ; Bing S. Ganb ; c ; David B. O&rsquo ; Gormanb ; c ; Roel A. Ophoffa ; d ; e ; Ophoff@ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Genetics ; GWAS ; Dupuytren&rsquo ; s contracture ; Ependymin ; FPCL
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：83
- 期：2
- 页码：131-137
- 全文大小：1081 K
文摘
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All three EPDR1 transcripts are detected in affected Dupuytren’s tissue.
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Dupuytren’s tissue contracts more in the FPCL paradigm.
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Knockdown of EPDR1 moderately attenuates late stage of contraction rate in FPCL.