Ketamine modulates hippocampal neurogenesis and pro-inflammatory cytokines but not stressor induced neurochemical changes
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- 作者：Melanie Clarke ; Sara Razmjou ; Natalie Prowse ; Zach Dwyer ; Darcy Litteljohn ; Rowan Pentz ; Hymie Anisman ; Shawn Hayley ; shawn_hayley@carleton.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Ketamine ; Stressor ; LPS ; Cytokine ; Neurogenesis
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：210-220
- 全文大小：988 K
文摘
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Effects of acute and repeated ketamine treatment in stress-exposed mice were examined.
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Repeated ketamine treatment prolonged antidepressant-like effects in a forced swim test.
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Ketamine did not alter stress-induced corticosterone or monoamine changes.
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Repeated ketamine treatment increased neurogenesis in the dentate gyrus of the hippocampus.
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Acute ketamine treatment reversed pro-inflammatory cytokine production.