Rat liver mitochondrial dysfunction by addition of copper(II) or iron(III) ions

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• 作者：Christian Saporito-Magriñ ; á ; Rosario Musacco-Sebio ; Juan M. Acosta ; Sofí ; a Bajicoff ; Paola Paredes-Fleitas ; Alberto Boveris ; Marisa G. Repetto ; ^{mrepetto@ffyb.uba.ar}
• 关键词：Mitochondria ; Liver oxidative stress and damage ; Oxygen consumption ; Copper ions ; Iron ions ; Metal toxicity
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：5-11
• 全文大小：737 K
• 卷排序：166

文摘

Cu(II) and Fe(III) addition to isolated rat liver mitochondria produced inhibition of mitochondrial respiration. Decreased mitochondrial respiration is maximal in O2 consumption in active state 3. Mitochondrial respiratory dysfunction is related to phospholipid peroxidation in mitochondria supplemented with Cu(II) and Fe(III). Different response to metal addition indicates different intracellular toxicity mechanisms. The direct impact on the organelle functionality of far lower concentrations of Cu than Fe suggests a dissociating event in the mechanism of toxicity of both metals.