Exertional Dyspnoea in Chronic Respiratory Diseases: From Physiology to Clinical Application

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• 作者：Bruno-Pierre Dubé ; ^a ; Franç ; ois Vermeulen^b ; Pierantonio Laveneziana^c ; ^d ; ^{pierantonio.laveneziana@psl.aphp.fr}
• 关键词：Chronic obstructive pulmonary disease ; Dynamic hyperinflation ; Dyspnoea ; Interstitial lung disease ; Pulmonary arterial hypertension ; Respiratory mechanics
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：2
• 页码：62-70
• 全文大小：1407 K
• 卷排序：53

文摘

Dyspnoea is a complex, highly personalised and multidimensional sensory experience, and its underlying cause and mechanisms are still being investigated. Exertional dyspnoea is one of the most frequently encountered symptoms of patients with cardiopulmonary diseases, and is a common reason for seeking medical help. As the symptom usually progresses with the underlying disease, it can lead to an avoidance of physical activity, peripheral muscle deconditioning and decreased quality of life. Dyspnoea is closely associated with quality of life, exercise (in)tolerance and prognosis in various conditions, including chronic obstructive pulmonary disease, heart failure, interstitial lung disease, and pulmonary hypertension, and is therefore an important therapeutic target.Effective management and treatment of dyspnoea is an important challenge for caregivers, and therapeutic options that attempt to reverse its underlying cause have been only partially successful This “review” will attempt to shed light on the physiological mechanisms underlying dyspnoea during exercise and to translate/apply them to a broad clinical spectrum of cardio-respiratory disorders.