Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

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• 作者：Jingkui Wang¹ ; ⁹ ; Daniel Mauvoisin² ; ⁹ ; ¹⁰ ; Eva Martin² ; Florian Atger² ; ³ ; Antonio Nú ; ñ ; ez Galindo⁴ ; Loï ; c Dayon⁴ ; Federico Sizzano⁵ ; Alessio Palini⁵ ; Martin Kussmann⁴ ; Patrice Waridel⁶ ; Manfredo Quadroni⁶ ; Vjekoslav Dulić⁷ ; Felix Naef¹ ; ¹⁰ ; ^{felix.naef@epfl.ch} ; Fr&eacute ; d&eacute ; ric Gachon² ; ⁸ ; ¹⁰ ; ¹¹ ; ^{frederic.gachon@rd.nestle.com}
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：102-117
• 全文大小：6368 K
• 卷排序：25

文摘

SILAC nuclear proteomics uncovered new diurnal regulatory landscape of mouse liver Regulation of the diurnal nuclear proteome is mostly post-translational Diurnal proteins regulate transcription, ribosome biogenesis, DNA repair, and cell cycle Hepatocyte polyploidy and size oscillate diurnally